发明名称 |
Method For Producing Thioether Compound |
摘要 |
Disclosed is an efficient and widely-applicable method for commercially producing a thioether compound or a thiol compound which is useful as a pharmaceutical compound or a production intermediate of it. Specifically disclosed is a method for producing a thioether compound represented by the general formula [I] below or a salt thereof. This method is characterized in that a compound represented by the following general formula [III]:[III] (wherein X represents a bromine atom, a chlorine atom or a trifluoromethylsulfonyloxy group, and ring A represents an aryl group or a heteroaryl ring group) or a salt thereof is reacted with a thiol compound represented by the following general formula [II]:[II] or a salt thereof in the presence of a palladium compound such as Pd<SUB>2</SUB>(dba)<SUB>3</SUB>, a base such as i-Pr<SUB>2</SUB>NEt and a phosphorus compound represented by the following formula [AA].
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申请公布号 |
US2008108823(A1) |
申请公布日期 |
2008.05.08 |
申请号 |
US20050664663 |
申请日期 |
2005.10.07 |
申请人 |
ITOH TAKAHIRO;MASE TOSHIAKI;AKAO ATSUSHI |
发明人 |
ITOH TAKAHIRO;MASE TOSHIAKI;AKAO ATSUSHI |
分类号 |
C07D213/70;C07C327/58;C07D209/04 |
主分类号 |
C07D213/70 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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