METHODS AND TOOLS FOR THE THERAPY OF NEURODEGENERATIVE PATHOLOGIES

摘要

The present invention relates to compositions and methods for the treatment of neurodegenerative pathologies in which the cognitive functions are affected, as observed in Alzheimer's disease. More particularly, the invention presents a strategy for observing the activity and/or the efficacy of neuroprotective treatments in human clinical studies, which strategy is based on the biochemical dosage of certain platelet parameters, more specifically the soluble APP-alpha (s-APP-alpha) form of the precursor amyloid protein, and can consequently be realized by means of blood draws. The invention also relates to methods, tools, constructions and compositions which are suitable for the realization of said strategies.