发明名称 |
Internalizing ErbB2 antibodies |
摘要 |
This invention provides novel erbB2-binding internalizing antibodies. The antibodies, designated F5 and C1, specifically bind to c-erbB2 antigen and, upon binding, are readily internalized into the cell bearing the c-erbB2 marker. Chimeric molecules comprising the F5 and/or C1 antibodies attached to one or more effector molecules are also provided. |
申请公布号 |
US2008108135(A1) |
申请公布日期 |
2008.05.08 |
申请号 |
US20070809773 |
申请日期 |
2007.06.01 |
申请人 |
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA |
发明人 |
MARKS JAMES D.;POUL MARIE ALIX |
分类号 |
C12N5/06;C12N15/09;A61K38/00;A61K39/395;A61K45/00;A61K47/48;A61P35/00;C07H21/04;C07K14/01;C07K16/28;C07K16/32;C07K19/00;C12N15/86 |
主分类号 |
C12N5/06 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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