TREATMENT OF CEREAL FLOUR AND SEMOLINA FOR CONSUMPTION BY CELIAC PATIENTS
摘要
The present invention relates to the use of an enzymatic method for treating flour, semolina and protein extracts derived from cereals known to stimulate a pathological immune response in patients affected by Celiac Disease (CD). Said treatment drastically reduces or completely eliminates the toxicity of gluten or similar products derived from other cereals. The method uses the catalytic activity of microbial transglutaminase and, in particular, its ability to bind proteins in cereal flour or semolina to an alkylated (C<SUB>1</SUB>-C<SUB>4</SUB>) derivative of lysine. After the treatment said proteins extracted from flour show a substantially lowered immuno-stimulatory activity in celiac patients T lymphocytes.
申请公布号
WO2008053310(A2)
申请公布日期
2008.05.08
申请号
WO2007IB03245
申请日期
2007.10.29
申请人
CONSIGLIO NAZIONALE DELLE RICERCHE;ROSSI, MAURO;GIANFRANI, CARMELA;SICILIANO, ROSA ANNA
发明人
ROSSI, MAURO;GIANFRANI, CARMELA;SICILIANO, ROSA ANNA