发明名称 |
Separation Of Ginkgolides And Bilobalide From G. Biloba |
摘要 |
The subject invention provides a method for separating a terpene trilactone from Ginkgo biloba plant material or from an extract of Ginkgo biloba comprising a mixture of terpene trilactones, the process comprising the steps of: a) subjecting the Ginkgo biloba plant material or the extract to column chromatography with an appropriate solvent system to produce at least a first fraction containing the terpene trilactone bilobalide, a second fraction eluted after the first fraction containing the terpene trilactones GA and GB, and a third fraction eluted after the second fraction containing at least a preponderance of the terpene trilactones GC and GJ; and b) alkylating the terpene trilactone GB of the second fraction so as to produce a first mixture including terpene trilactone GA and alkylated terpene trilactone GB; or alkylating the terpene trilactone GC of the third fraction so as produce a second mixture including terpene trilactone GJ and alkylated terpene trilactone GC, so as to thereby isolate a terpene trilactone.
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申请公布号 |
US2008108837(A1) |
申请公布日期 |
2008.05.08 |
申请号 |
US20040579162 |
申请日期 |
2004.11.09 |
申请人 |
THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK |
发明人 |
NAKANISHI KOJI;JARACZ STANISLAV;MALIK SHAHID;ISHII HIDEKI;DZYUBA SERGEI V. |
分类号 |
C07D407/14;B01D;C07D307/77;C07D307/93;C07D307/94 |
主分类号 |
C07D407/14 |
代理机构 |
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