摘要 |
Methods and compositions for systemically or locally administering a beneficial agent to a subject are described, and include, for example, implantable elastomeric depot compositions that can be injected into a desired location and which can provide controlled release of a beneficial agent over a prolonged duration of time. The compositions include a biocompatible, elastomeric caprolactone copolymer, a biocompatible solvent having low water miscibility that forms an elastomeric viscous gel with the polymer and limits water uptake by the implant, and a beneficial agent. |
申请人 |
ALZA CORPORATION;CHEN, GUOHUA;KLEINER, LOTHAR WALTER;HOUSTON, PAUL, R.;NATHAN, ARUNA;ROSENBLATT, JOEL |
发明人 |
CHEN, GUOHUA;KLEINER, LOTHAR WALTER;HOUSTON, PAUL, R.;NATHAN, ARUNA;ROSENBLATT, JOEL |