A microbe contamination detection system is described. The microbe contamination detection system alerts a user or other individual in the event of microbial contamination of the system. The signal graphic is revealed when an obscuring graphic reacts with the microbial contamination to change color and/or become at least substantially transparent. The microbe contamination detection system may be used as a stand-alone device or may be incorporated as part of various articles or products, for instance, health care or food service preparation protective garments. Methods for using the microbe contamination detection system are also described.
