THIADIAZOLE COMPOUNDS AND METHODS OF USE THEREOF

摘要

The present invention relates to Thiadiazsle Compounds having, for examples the Formula; compositions comprising an effective dose of a Thiadiazole Compound; and methods treating or preventing a metalloproteinase- related disorder, such as, an arthritic disorder, osteoarthritis, cancer, rheumatoid arthritis, asthma, chronic obstructive pulmonary disease, atherosclerosis, age- related macular degeneration, myocardial infarction, a corneal ulceration, an ocular surface disease, hepatitis, an aortic aneurysm, tendonitis, a central nervous system disorder, abnormal wound healing, angiogenesis, restenosis, cirrhosis, multiple sclerosis, glomerulonephritis, graft versus host disease, diabetes, an inflammatory bowel disease, shock, invertebral disc degeneration, stroke, osteopenia or a periodontal disease or comprising administering- an effective dose of a Thiadiazole Compound to a mammal in need thereof.