发明名称 |
Human Cytomegalovirus Immunotherapy |
摘要 |
An isolated protein construct comprising a polyepitope derived from multiple human cytomegalovirus protein antigen epitopes conjugated to an extracellular domain of glycoprotein B, which isolated protein is capable of eliciting a cytotoxic T-lymphocyte immune response as well as a neutralizing antibody response to human cytomegalovirus. Also provided are pharmaceutical compositions comprising the isolated protein or an adenoviral expression construct for delivery and expression of a nucleic acid encoding the isolated protein for prophylactic and/or therapeutic treatment of human cytomegalovirus infection, particularly in humans.
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申请公布号 |
US2008107620(A1) |
申请公布日期 |
2008.05.08 |
申请号 |
US20050720421 |
申请日期 |
2005.11.29 |
申请人 |
THE COUNCIL OF THE QUENSLAND INSTITUTE OF MEDICALRESEARCH, THE BANCROFT CENTRE |
发明人 |
KHANNA RAJIV |
分类号 |
A61K39/245;A61K38/16;A61K38/19;A61K48/00;A61P37/02;C07K14/045;C12N5/10;C12N15/38;C12N15/861;C12N15/863 |
主分类号 |
A61K39/245 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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