DITHIOLE COMPOUNDS AS COX INHIBITORS

摘要

A compound of formula (I) wherein: R<SUB>1</SUB> and R<SUB>2</SUB> are the same or different and are independently selected from H and a shielding group; X and Y are each independently selected from N and CH; R<SUB>3</SUB> is hydroxy, alkoxy, acyloxy or an ester group; R<SUB>4</SUB> is a direct bond to R<SUB>5</SUB>, -CH<SUB>2</SUB>- or -CH=; the broken line ----- represents an optional double bond between R<SUB>4</SUB> and R<SUB>5</SUB>; and R<SUB>5</SUB> is a 5- or 6-membered substituted or unsubstituted unsaturated heterocyclic or heteroaromatic ring, or R<SUB>5</SUB> is a substituted heterocyclic ring containing the substituent = O or = S, wherein the heteroatom is selected from S, O or P, and wherein R<SUB>5</SUB> is optionally attached to R<SUB>4</SUB> through a substituent on the heterocyclic or heteroaromatic ring; or a pharmaceutically acceptable prodrug, metabolite, ester, salt, derivative, tautomer or isomer thereof. The compounds have utility as COX-inhibitors and for use in the treatment of pain, inflammation or a neurodegenerative disease.