摘要 |
<p>The invention relates to a improved process for the preparation of Losartan and its potassium salt, which comprises (i) reacting bromo OTBN with BCFI in the presence of a base and a phase transfer catalyst to get cyano aldehyde, reacting the cyano aldehyde sodium azide in the presence of tributyl tin chloride to form aldehyde tetrazole, reducing the aldehyde tetrazole with sodium borohydride to give Losartan and, if desired, converting it to its potassium salt by known method.</p> |