CONTROLLED RELEASE COMPLEX COMPOSITION COMPRISING ANGIOTENSIN-II-RECEPTOR BLOCKERS AND HMG-COA REDUCTASE INHIBITORS

摘要

A controlled release complex composition comprising an angiotensin-II-receptor blocker and an HMG-CoA reductase inhibitor is provided to be designed to control each of the ingredients releasing at a specific rate by administering the ingredients to have different onset times and be very effective for treating hypertension and preventing complications in patients having metabolic syndromes which show diabetes, obesity, hyperlipidemia, coronary artery diseases and the like. A controlled release complex composition comprises a lag time delayed-release portion including an angiotensin-II-receptor blocker as an active ingredient and an immediate release portion including an HMG-CoA reductase inhibitor as an active ingredient, wherein the angiotensin-II-receptor blocker is selected from the group consisting of losartan, valsartan, irbesartan, candesartan, telmisartan, eprosartan, olmesartan and a pharmaceutically acceptable salt thereof, the HMG-CoA reductase inhibitor is at least one selected from the group consisting of simvastatin, lovastatin, atorvastatin, pitavastatin, rosuvastatin, fluvastatin, pravastatin and a pharmaceutically acceptable salt thereof and the lag time delayed-release portion includes a release-controlling material selected from the group consisting of an enteric polymer, a water-insoluble polymer, a hydrophobic compound and a hydrophilic polymer. Further, the 5 to 1200 mg of angiotensin-II-receptor blocker is comprised in the composition.