发明名称 |
Detection of biospecific interactions using amplified differential time domain spectroscopy signal |
摘要 |
A method for detecting specific associations between a tethered molecule and an untethered target molecule. The method comprises (1) selecting a tethered molecule; (2) alternately impinging THz radiation onto the tethered molecule and onto a sample including the tethered and untethered target molecules; (3) detecting the radiation impinged on the tethered molecule to form a reference signal and the radiation impinged on the sample to form a sample signal; and (4) comparing the reference signal with the sample signal to generate a specimen signal indicative of an association between the selected tethered and target molecules. The method will detect whether a selected tethered molecule and the desired target exhibit any affinity or, in cases where the affinity is known, will detect the presence of the target molecule in a sample. Also provided is an apparatus for detecting specific associations between a tethered molecule and an untethered target molecule. |
申请公布号 |
US7368280(B2) |
申请公布日期 |
2008.05.06 |
申请号 |
US20040515607 |
申请日期 |
2004.11.23 |
申请人 |
RENSSELAER POLYTECHNIC INSTITUTE |
发明人 |
ZHANG XI-CHENG;MICKAN SAMUEL PETER;MENIKH ABDELLAH |
分类号 |
C12M1/34;C12M3/00;G01N21/35;G01N33/543 |
主分类号 |
C12M1/34 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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