Dinucleoside poly(borano)phosphate derivatives and uses thereof

摘要

The present invention provides dinucleoside boranophosphate derivatives of the general formula I: wherein X and X' each independently is an unsubstituted or substituted purine or pyrimidine residue; Y and Y' each independently is H or OH; Z₁ to Z₅ each independently is O^- or BH₃^-, but excluding the compounds wherein Z₁ to Z₅ are each O^-; W₁ to W₄ each independently is O, CH₂, NH or C(Halogen)₂; n and n' each independently is 0 or 1; m is 3, 4 or 5; and M⁺ represents a pharmaceutically acceptable cation, and to pharmaceutical compositions thereof. These dinucleoside boranophosphates are useful for prevention or treatment of diseases or disorders modulated by P2Y receptors such as type 2 diabetes, cystic fibrosis and cancer.