发明名称 |
SLC1A1 marker for anxiety disorder |
摘要 |
The present invention provides methods for diagnosing or identifying susceptibility of a subject to an anxiety or mood disorder. One method involves testing a sample obtained from the subject for the presence of a polymorphism in Intron 10 of the SLC1A1 gene. The presence of allele G or allele A of the A/G polymorphism rs301434 indicates that the patient is susceptible to an anxiety disorder. An alternate method involves testing a sample obtained from the subject for the presence of a polymorphism in the 3' untranslated region of the SLC1A1 gene. The presence of allele C of C/G polymorphism rs3087879 indicates that the patient is susceptible to an anxiety disorder. Furthermore, a method is provided that involves testing a sample obtained from the subject for the presence of a haplotype in the SLC1A1 gene, wherein the combined presence allele G of the A/G polymorphism rs301434 and allele C of C/G polymorphism rs3087879 indicates that the patient is susceptible to a mood disorder. |
申请公布号 |
US7368264(B2) |
申请公布日期 |
2008.05.06 |
申请号 |
US20060591244 |
申请日期 |
2006.10.31 |
申请人 |
CENTRE FOR ADDICTION AND MENTAL HEALTH |
发明人 |
ARNOLD PAUL DANIEL;RICHTER MARGARET A.;KENNEDY JAMES LOWERY |
分类号 |
C12P19/34 |
主分类号 |
C12P19/34 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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