发明名称 |
MULTIMERIC TIE 2 AGONISTS AND USES THEREOF IN STIMULATING ANGIOGENESIS |
摘要 |
The present invention provides a multimeric form of a Tie 2 binding peptide monomer, wherein the multimeric form has Tie 2 agonist activity. The multimeric form, preferably a tetramer, stimulates angiogenesis and promotes wound healing. The present invention also features pharmaceutical compositions comprising the multimeric Tie 2 agonists, including those suitable for topical or systemic administration. Methods of using the multimeric Tie 2 agonists of the invention for stimulating angiogenesis and for promoting healing of wounds, such as diabetic ulcers or skin grafts, are also provided. |
申请公布号 |
WO2008049227(A1) |
申请公布日期 |
2008.05.02 |
申请号 |
WO2007CA01903 |
申请日期 |
2007.10.26 |
申请人 |
SUNNYBROOK HEALTH SCIENCES CENTER;VAN SLYKE, PAUL;DUMONT, DANIEL |
发明人 |
VAN SLYKE, PAUL;DUMONT, DANIEL |
分类号 |
A61K47/48;A61K38/17;A61L27/60;A61P9/00;A61P17/02;A61P39/00;G01N33/577 |
主分类号 |
A61K47/48 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|