发明名称 |
PROCESS FOR THE PREPARATION OF SUCRALOSE BY THE CHLORINATION OF SUGAR WITH TRIPHOSGENE (BTC) |
摘要 |
In one embodiment of the invention a method to prepare sucralose-6-acylate through chlorinating sucrose-6-acylater by BTC in the process of sucralose preparation is disclosed. In this embnodiment a Vilsmeier reagent is firstly prepared belowe 0 °C by dissolving BTC in DMF or in component solvent, containing DMF, toluene, dichloroethane, chloroform and carbon tetrachloride. Consequently, sucrose-6-ester was chlorinated by Vilsmeier reagent. BTC can also be dissolved in one or several organic solvent such as toluene, dichloroethane, chloroform and carbon tetrachloride, and added to a DMF solution of sucrose-6-acylate for chlorination. Sucralose was prepared through de-esterifying the obtained sucralosed 6-ester using sodium methoxide/methanol or sodium ethoxide/ethanol. |
申请公布号 |
WO2008052076(A2) |
申请公布日期 |
2008.05.02 |
申请号 |
WO2007US82422 |
申请日期 |
2007.10.24 |
申请人 |
MAMTEK INTERNATIONAL LIMITED;HO, DAVID LOSAN;WANG, ZHENGHAO |
发明人 |
HO, DAVID LOSAN;WANG, ZHENGHAO |
分类号 |
C07H1/00;A23L27/30;C07H5/02 |
主分类号 |
C07H1/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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