| 摘要 |
<p>A chelating compound of the formula ma-Xaa1-Xaa2-Xaa3-R is provided, wherein - ma is mercaptoacetyl; - Xaa1, Xaa2 and Xaa3 are amino acid residues defined as follows: o any one or two of Xaa1, Xaa2 and Xaa3 is/are the amino acid residue Ser; o in case two of Xaa1, Xaa2 and Xaa3 are Ser, the remaining amino acid residue is selected from the group consisting of Glu, Arg and Lys; o in case one of Xaa1, Xaa2 and Xaa3 is Ser, the remaining amino acid residues are both Glu; and - R has a biological function and is selected from the group consisting of polypeptides, PNA, DNA, RNA, and mixtures thereof. Also provided are chelates of this compound with radioactive metal atoms, as well as methods and uses employing the chelating compound.</p> |
