发明名称 |
ISOLATED HYDROXY AND N-OXIDE METABOLITES AND DERIVATIVES OF O-DESMETHYLVENLAFAXINE AND METHODS OF TREATMENT |
摘要 |
The present invention provides novel isolated compounds characterized as metabolites or derivatives of desmethylvenlafaxine including hydroxy-DV meta bolites, hydroxy-DV-glucuronide metabolites, N-oxide-DV metabolites, and ben zyl-hydroxy-DV metabolites. The invention includes pharmaceutical compositio ns comprising any of the metabolites or derivatives of the invention in comb ination with a pharmaceutically acceptable carrier or excipient. The inventi on also includes a method of treating at least one central nervous system di sorder in a mammal comprising providing to a mammal in need thereof an effec tive amount of the compounds of the invention.
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申请公布号 |
CA2666350(A1) |
申请公布日期 |
2008.05.02 |
申请号 |
CA20072666350 |
申请日期 |
2007.10.24 |
申请人 |
WYETH |
发明人 |
HOFFMANN, MATTHEW JOHN;DEMAIO, WILLIAM;ULLRICH, JOHN WILLIAM;WANG, JIM |
分类号 |
C07C215/64;A61K31/095;A61K31/135;A61K31/351;C07C291/02;C07C305/20;C07C305/24 |
主分类号 |
C07C215/64 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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