AMINOPYRAZOLE DERIVATIVES, PROCESS FOR THE PREPARATION THEREOF, AND COMPOSITION FOR PREVENTING OR TREATING AN ISCHEMIC DISEASE CONTAINING THE SAME

摘要

Aminopyrazole derivatives are provided to reduce ischemic apoptosis significantly and protect internal organs, so that the derivatives are useful for preventing or treating ischemic diseases mediated by ischemic apoptosis. The aminopyrazole derivatives represented by the formula(1) or pharmaceutically acceptable salts are provided in order to prevent or treat ischemic diseases, wherein R^1 is -CO2R^3, -CH2OR^3, -CONR^3R^4 or a structural formula in which R^3 and R^4 are each independently H or C1-C6 linear, branched or cyclic alkyl; R^2 is -(CH2)m Ar or C1-C6 linear, branched or cyclic alkyl in which m is an integer from 1 to 3 and Ar is phenyl or C1-C3 alkyl or halogen substituted phenyl; B is H, phenyl or C1-C3 alkyl or halogen substituted phenyl; n is an integer from 0 to 2; Y is S, O, C, SO, SO2 or NR^3R^4; Z is H, halogen, OCH3, NO2, NH2 or C1-C3 linear or branched alkyl; and A is CH or N.