OXADIAZOLE AND THIADIAZOLE COMPOUNDS AND THEIR USE AS NICOTINIC ACETYLCHOLINE RECEPTOR MODULATORS

摘要

This invention relates to oxadiazolyl and thiadiazolyl derivatives, which are found to be modulators of the nicotinic acetylcholine receptors. Due to their pharmacological profile the compounds of the invention may be useful for the treatment of diseases or disorders as diverse as those related to th e cholinergic system of the central nervous system (CNS), the peripheral ner vous system (PNS), diseases or disorders related to smooth muscle contractio n, endocrine diseases or disorders, diseases or disorders related to neuro-d egeneration, diseases or disorders related to inflammation, pain, and withdr awal symptoms caused by the termination of abuse of chemical substances.