ORGANIC NANOPARTICLES OBTAINED FROM MICROEMULSIONS BY SOLVENT EVAPORATION

摘要

The invention provides a process for preparing a redispersible powder comprising nanoparticles of a water-insoluble organic compound, the process comprising the steps of : (i) preparing an oil-in-water microemulsion comprising a water-insoluble organic compound, a volatile water- immiscible organic solvent, water, and at least one surfactant; and (ii) removing the volatile water- immiscible organic solvent and the water so as to form the redispersible powder comprising said nanoparticles, wherein said nanoparticle are in a particulate form, and wherein the solubility of the water-insoluble organic compound is at least about 5 times greater than the solubility of the water-insoluble organic compound in unprocessed form. Step (i) can further comprise the addition of co-solvent or polymer. The water-insoluble organic compound can be selected from the group consisting of pharmaceutically active agent (in particular a statin), cosmetic active agents, anti oxidants, preservatives, colorants, food additives, agriculturally active compounds and fragrances.