GENOMIC DNA FRAGMENT CONTAINING REGULATORY AND CODING SEQUENCE FOR beta2-SUBUNIT OF NEURONAL NICOTINIC ACETYLCHOLINE RECEPTOR, AND TRANSGENIC ANIMAL MADE BY USING THE FRAGMENT OR MUTATED FRAGMENT

摘要

PROBLEM TO BE SOLVED: To acquire useful information on the pharmacological effect of nicotine, the role of nAChR, dementia relating to nicotine addiction and nicotine deficiency, etc., by expressing a DNA containing a sequence for regulating a β2-subunit of nAChR and a sequence encoding the subunit and to provide a DNA, etc., effective for screening a compound recovering or controlling the activity and action relating to the nAChR.

SOLUTION: The invention provides an isolated DNA containing a promoter of a β2-subunit of the nAChR composed essentially of a specific base sequence and a sequence hybridizing to the DNA under a stringent condition, a recombinant vector containing the DNA, a transformed organic material, a transgenic non-human mammal containing the transformed organic material introduced in the mammal, etc.

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