PROCESS FOR THE PREPARATION OF SUCROSE-6-ESTER BY ESTERIFICATION IN THE PRESENCE OF SOLID SUPERACID CATALYST

摘要

One embodiment of the present invention is a process of making sucrose-6-ester from sucrose by transesterification in the presence of a solid super acid catalyst such as SO₄^2--TiO₂/Al₂O₃ or SO₄^2--TiO₂. The sucrose-6-acetate is then chlorinated to afford sucralose-6-acetate, using BTC or thionyl chloride. Sucralose-6-acetate is converted into TPSGA for the purpose of purification. TPSGA is de-esterified by sodium methoxide/methanol or sodium ethoxide/ethanol to give sucralose.