发明名称 Combination of a DPP IV inhibitor and a cardiovascular compound
摘要 Disclosed is a combination of (S)-1-[(3-hydroxy-1-adamantyl)amino]acetyl-2-cyano-pyrrolidine or a pharmaceutically acceptable salt thereof and at least one therapeutic agent selected from the group consisting of losartan, olmesartan, benazepril, enalapril, lisinopril, ramipril, aliskiren, metoprolol, doxoazosin, amlodipine, fadrozole, (+)-enantiomer of fadrozole, eplerenone, candoxatril, sinorphan, omapatrilat, bosentan and hydrochlorothiazide. The combination is useful in the prevention or treatment of hypertension. (62) Divided Out of 536758
申请公布号 NZ548971(A) 申请公布日期 2008.04.30
申请号 NZ20030548971 申请日期 2003.05.28
申请人 NOVARTIS AG 发明人 HOLMES, DAVID;SHETTY, SURAJ SHIVAPPA;HUGHES, THOMAS EDWARD
分类号 A61K45/06;A61K31/16;A61K31/40;A61K31/401;A61K31/41;A61K31/4439;A61K31/454;A61P3/04;A61P3/06;A61P3/10;A61P5/14;A61P7/02;A61P9/00;A61P9/04;A61P9/10;A61P9/12;A61P13/12;A61P15/10;A61P17/00;A61P19/04;A61P27/02;A61P27/06;A61P27/12;(IPC1-7):A61K31/40 主分类号 A61K45/06
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