发明名称 BIOACTIVE PRODUCT WITH ANTIULCEROUS ACTIVITY AND PROCESS FOR PREPARING THE SAME
摘要 <p>The invention relates to a bioactive product with antiulcerous activity comprising 40...50% m/m total flavones expressed as rutoside, 2...4%m/m polyphenol carboxylic acids expressed as caffeic acid, proteins and minerals. The process for preparing the claimed product consists in sucessively extracting the dry and ground vegetable material consisting of a 1 : 1 m/m mixture of the species Centaurea cyanus L-herba and Plantago lanceolata L-folium, twice with distilled water, at an extraction ratio of 1 : 17 m/v, and twice with a distilled water : acetone mixture, at a solvent ratio 1 : 2 and 1 : 1 v/v, respectively, and an extraction ratio of 1 : 15 m/v, at the reflux temperature of solvents and under stirring, isolating the polysaccharidic fraction by precipitating the aqueous extracts coalesced with polar solvents, isolating the polyphenolic fraction consisting of the ethyl acetate-soluble fraction extracted from the coalesced filtrates resulting from polysaccharide precipitation, and the aqueous fraction resulting from the extraction of coalesced hydroacetonic extracts with dichloro-methane, and coalescing the polysaccharidic fractions with the polyphenolic fraction.</p>
申请公布号 RO121764(B1) 申请公布日期 2008.04.30
申请号 RO20020000059 申请日期 2002.01.24
申请人 INSTITUTUL NA IONAL DE CERCETARE-DEZVOLTARE CHIMICO-FARMACEUTIC E 发明人 PAAERVU LUCIA CAMELIA;COPREAN DRAGOMIR;CHIOPU STELIAN;PINTILIE GABRIELA;COLCERU MIHUL SVETLANA GABRIELA;ALEXANDRU NICOLETA
分类号 A61K36/00;A61P1/04 主分类号 A61K36/00
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