发明名称 |
(E)-N-Monoalkyl-3-oxo-3-(2-thienyl)propenamine and process for producing the same and (E,Z)-N-monoalkyl-3-oxo-3-(2-thienyl)propenamine and process for producing the same |
摘要 |
The present invention provides a process for producing (E)-N-monoalkyl-3-oxo-3-(2-thienyl)propenamine represented by Formula (1);
wherein R is a C 1-4 alkyl,
the method comprising the steps of:
maintaining a solution containing (Z)-N-monoalkyl-3-oxo-3-(2-thienyl)propenamine dissolved therein at 25°C or below to deposit crystals and separating crystals having a particle diameter of 100 µm or less from the deposited crystals; and a process for producing (E,Z)-N-monoalkyl-3-oxo-3-(2-thienyl)propenamine comprising the steps of:
reacting an alkali metal salt of ²-oxo-²-(2-thienyl)propanal with a monoalkylamine compound; adding a water-insoluble organic solvent to the resulting reaction mixture; adding seed crystals containing (E)-N-monoalkyl-3-oxo-3-(2-thienyl)propenamine to an organic layer obtained by conducting separation; and keeping the resulting mixture at 25°C or below.
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申请公布号 |
EP1916243(A1) |
申请公布日期 |
2008.04.30 |
申请号 |
EP20060782103 |
申请日期 |
2006.08.01 |
申请人 |
SUMITOMO SEIKA CHEMICALS CO., LTD. |
发明人 |
SATAKE, SYUZO;HAYASHIZAKA, NORIYUKI;FUSEYA, ICHIRO;TANAKA, MUNEAKI;KAGANO, HIROKAZU |
分类号 |
C07D333/22 |
主分类号 |
C07D333/22 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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