发明名称 |
N-terminally monopegylated human growth hormone conjugates, process for their preparation, and methods of use thereof. |
摘要 |
The present invention provides a chemically modified human Growth Hormone (hGH) prepared by attaching a polyethylene glycol butyraldehyde moiety to the N-terminal phenylalanine of the protein. The chemically modified protein according to the present invention may have a much longer lasting hGH activity than that of the un-modified hGH, enabling reduced dose and scheduling opportunities. The present invention also includes methods of use for the treatment and/or prevention of diseases or disorders in which use of growth hormone is beneficial.
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申请公布号 |
EP1915999(A1) |
申请公布日期 |
2008.04.30 |
申请号 |
EP20070110559 |
申请日期 |
2005.01.24 |
申请人 |
PHARMACIA CORPORATION |
发明人 |
FINN, RORY, F. |
分类号 |
A61K38/27;A61K47/48;C07K14/61 |
主分类号 |
A61K38/27 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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