摘要 |
Disclosed is a compound of formula (II) or (II'), wherein R1 is hydrogen, R2 is a substituted phenyl or a substituted 3-7-membered saturated or partially unsaturated monocyclic ring having 0-3 heteroatoms selected from nitrogen, oxygen, or sulfur, or an 8-12-membered saturated or partially unsaturated bicyclic ring system having 0-5 heteroatoms independently selected from nitrogen, oxygen or sulfur, and the remaining substituents are as defined in the specification. The compounds are useful as inhibitors of protein kinases.
|
申请人 |
VERTEX PHARMACEUTICALS INCORPORATED |
发明人 |
PIERCE, ALBERT C;ARNOST, MICHAEL;DAVIES, ROBERT J;FORSTER, CORNELIA J;GALULLO, VINCENT;GREY, RONALD;LEDEBOER, MARK;TIAN, SHI-KAI;XU, JINWANG;BINCH, HAYLEY;LEDFORD, BRIAN;MESSERSMITH, DAVID;NANTHAKUMAR, SUGANTHI;JAYARAJ, ANDREW;WANG, JIAN;SALITURO, FRANCESCO G;HENKEL, GREG |