发明名称 |
ANTISENSE ANTIBACTERIAL METHOD AND COMPOUND |
摘要 |
An antibacterial antisense conjugate and method of using the same for treating a bacterial infection in a mammalian host are disclosed. The conjugate includes an antisense oligonucleotide conjugated to a carrier peptide that significantly enhances the antibacterial activity of the oligonucleotide. The antisense oligonucleotide contains 10-20 nucleotide bases and has a targeting nucleic acid sequence complementary to a target sequence containing or within 10 bases, in a downstream direction, of the translational start codon of a bacterial mRNA that encodes a bacterial protein essential for bacterial replication, where the compound binds to a target mRNA with a Tm of between 50° to 600C. The carrier peptide is an arginine-rich peptide containing between 6 and 12 amino acids. |
申请公布号 |
EP1915161(A2) |
申请公布日期 |
2008.04.30 |
申请号 |
EP20060787433 |
申请日期 |
2006.07.13 |
申请人 |
AVI BIOPHARMA, INC. |
发明人 |
GELLER, Bruce, L.;TILLEY, Lucas, D.;IVERSEN, Patrick, L. |
分类号 |
A61K31/70;C07H21/02;C07H21/04;C12N5/00;C12Q1/68 |
主分类号 |
A61K31/70 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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