Newcastle disease virus comprising a plurality of doses for treating a mammalian subject having a tumour

摘要

The use, in the manufacture of a pharmaceutical preparation, of a Newcastle disease virus for treating a mammalian subject having a tumor, wherein said pharmaceutical preparation comprises a plurality of doses of an amount of the Newcastle disease virus effective to treat the subject, wherein the plurality of doses are adapted for administration in one or more cycles, wherein at least one cycle of the pharmaceutical preparation comprises one or more desensitization doses and one or more escalated doses of the virus; wherein the amount of the virus in each escalated dose is higher than the amount of virus in each desensitization dose; and the first escalated dose of the pharmaceutical preparation is adapted for administration to the subject from 18 to 36 hours after the first desensitization dose.