发明名称 |
Transgenic Mouse for screening and for studies of the pharmacodynamics and pharmacokinetics of ligands acting on intracellular receptors, and method for the preparation thereof |
摘要 |
The object of the invention is a method for the production of a non-human transgenic mammal by means of which it is possible to monitor in vivo and in all the tissues the state of activation of any intracellular receptor, utilizing a reporter gene inducible by natural or synthetic molecules which modulate the activity of such receptor. The mammal is question is preferably a mouse. |
申请公布号 |
EP1913813(A1) |
申请公布日期 |
2008.04.23 |
申请号 |
EP20070119471 |
申请日期 |
2001.07.02 |
申请人 |
TOP (TRANSGENIC OPERATIVE PRODUCTS) S.R.L. |
发明人 |
MAGGI, ADRIANA CATERINA;CIANA, PAOLO |
分类号 |
A01K67/027;C12N5/10;C12N15/85;G01N33/50 |
主分类号 |
A01K67/027 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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