发明名称 |
CELL/LIGAND MARKING SYSTEM, WHEREIN THE MARKER IS OF EPH TYPE, CELL MATERIAL COMPRISING SAID SYSTEM, METHOD FOR PREPARING SAME AND PROANGIOGENETIC USE |
摘要 |
<p>A cell/ligand specific marking system, the system being characterized in that it comprises: (a) an endothelial precursor cell (EPC) including a cell marker selected from among the group consisting of the Eph (in particular EphB4 or EphB1), and (b) a protein material of structure L-K, which consists of a ligand (L) specific of the marker and is associated or fused with a binding protein (K), the system being capable of providing a proangiogenetic cell material of structure EPC-Eph-L-K. The invention also concerns the cell material as product capable of stimulating angiogenesis, its preparation method and its therapeutic use, in particular with respect to vascular insufficiencies.</p> |
申请公布号 |
EP1913130(A2) |
申请公布日期 |
2008.04.23 |
申请号 |
EP20060794234 |
申请日期 |
2006.07.27 |
申请人 |
INSTITUT DES VAISSEAUX ET DU SANG;UNIVERSITE PARIS 7 - DENIS DIDEROT |
发明人 |
FOUBERT, PHILIPPE;SILVESTRE, JEAN-SEBASTIEN;LE RICOUSSE-ROUSSANNE, SOPHIE |
分类号 |
C12N5/071;A61K35/44;A61K47/48;C12N5/074 |
主分类号 |
C12N5/071 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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