Antibacterial 1-(4-mono- and di-halomethylsulphonylphenyl)-2-acylamino-3-fluoroproponals and preparation thereof

摘要

Novel florfenicol compounds having the chemical structure: or a pharmaceutically-acceptable salt thereof or a solvate thereof, or prodrug thereof, wherein R¹ is CHCl₂, CHClF, CHF₂, CHBrCl, CH₃, CH₂N₃, CH₂CN, CH(R²)NH₂ or CH X¹X²; where R² is H, CH₃ or CH₂OH, and X¹ and X² are independently selected halogens; and R³ is CH₂Cl, CH₂F, CHF₂, CHCl₂ or CH₂OH are disclosed. The compounds are useful for the treatment and/or prevention of bacterial infections in a broad range of patients such as, without limitation, birds, fish, shellfish and mammals.