| 发明名称 |
Heteroarylacetamide inhibitors of factor Xa |
| 摘要 |
The invention is concerned with novel heteroarylacetamides of formula (I) <?in-line-formulae description="In-line Formulae" end="lead"?>R<SUP>d</SUP>-C(O)-N(R<SUP>e</SUP>)-R<SUP>c</SUP>-CH<SUB>2</SUB>-C(O)-N(R<SUP>a</SUP>)(R<SUP>b</SUP>) (I)<?in-line-formulae description="In-line Formulae" end="tail"?> wherein R<SUP>a </SUP>to R<SUP>e </SUP>are as defined in the description and in the claims, as well as physiologically acceptable salts thereof. These compounds inhibit the coagulation factor Xa and can be used as medicaments.
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| 申请公布号 |
US7361672(B2) |
申请公布日期 |
2008.04.22 |
| 申请号 |
US20050301560 |
申请日期 |
2005.12.13 |
| 申请人 |
HOFFMANN-LA ROCHE INC. |
发明人 |
BOEHRINGER MARKUS;ZBINDEN KATRIN GROEBKE;HAAP WOLFGANG;HILPERT HANS;PANDAY NARENDRA;RICKLIN FABIENNE |
| 分类号 |
C07D401/14;A61K31/4155;A61K31/4192;A61K31/4196;A61K31/4427;C07D231/38;C07D249/04;C07D249/14;C07D257/06 |
主分类号 |
C07D401/14 |
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