摘要 |
A method for identifying a selective persistent Na<SUP>+</SUP> channel blocker by measuring the ability of the blocker to reduce or inhibit a persistent Na<SUP>+</SUP> current to a greater degree than a transient Na<SUP>+</SUP> current. Aspects of the present method provide Na<SUP>+</SUP> depletion/repletion methods for identifying a selective blocker of a persistent Na<SUP>+</SUP> channel, hyperpolarization methods for identifying a blocker of a persistent Na+ channel, and Na/K ATPase pump inhibitor methods for identifying a selective blocker of a persistent Na<SUP>+</SUP> channel.
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