发明名称 |
ESTRONE SULFAMATE INHIBITORS OF ESTRONE SULFATASE, AND ASSOCIATED PHARMACEUTICAL COMPOSITIONS AND METHODS OF USE |
摘要 |
Novel compounds useful as inhibitors of estrone sulfatase are provided. The compounds have structural formula (I) wherein r1 is an optional double bond, R1 and R2 are selected from the group consisting of hydrogen and lower alkyl, or together form a cyclic substituent (II) wherein Q is NH, O or CH2, and the other various substituents are as defined herein. Pharmaceutical compositions and methods for using the compounds of formula (1) to treat estrogen-dependent disorders are provided as well.
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申请公布号 |
CA2318349(C) |
申请公布日期 |
2008.04.22 |
申请号 |
CA19982318349 |
申请日期 |
1998.12.21 |
申请人 |
SRI INTERNATIONAL |
发明人 |
PETERS, RICHARD H.;CHAO, WAN-RU;SHIGENO, KAZUHIKO;TANABE, MASATO |
分类号 |
A61K31/565;C07J41/00;A61K31/57;A61K31/575;A61P5/30;A61P35/00;A61P43/00 |
主分类号 |
A61K31/565 |
代理机构 |
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主权项 |
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地址 |
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