2-, 3-, 4-, OR 5-SUBSTITUTED-N1-BENZENSULFONYLINDOLES AND THEIR USE IN THERAPY

摘要

The invention provides 2, 3-, 4- or 5-substituted-N1-(arylsulfonyl)indole and (heteroaryl)indole compounds of the general formula (I): in which Ar, R², R³, R⁴ and R⁵ are as defined in the specification. The compounds bind to the 5-HT₆ receptor and are useful for the treatment and prophylaxis of disorders mediated by the 5-HT₆ receptor, such as obesity and CNS disorders.