MOLECULAR MIMETICS OF MENINGOCOCCUS B EPITOPE THAT INDUCE PRODUCTION OF FUNCTIONALLY ACTIVE ANTIBODY

摘要

FIELD: medicine, immunology, chemistry of peptides. ^ SUBSTANCE: invention discloses peptides GNA33 representing mimetics of epitopes of microorganisms Neisseria meningitides of the serogroup B showing definite amino acid sequences given in the description and able to induce production of antibodies eliciting complement-mediated bactericidal activity and/or opsonic activity against indicated microorganisms in a mammalian subject. Indicated peptides are used as components of a composition used in a method for production of the immune response reaction against indicated microorganisms in a mammalian subject. Also invention concerns a polynucleotide encoding indicated peptide and recombinant expression vector comprising indicated polynucleotide. Also invention discloses a method for preparing peptide GNA33 by culturing the cell-host comprising recombinant expression vector and assay for the presence of antibodies raised against meningococci B in biological sample using GNA33 peptide. Using the invention provides effectiveness of vaccine raised against MenB and safety for its using for a patient. ^ EFFECT: valuable biological and medicinal properties of peptides. ^ 11 cl, 6 tbl, 8 dwg, 6 ex