MEDICAL DEVICES INCORPORATING A BIOACTIVE AND METHODS OF PREPARING SUCH DEVICES
摘要
One embodiment provides a medical device comprising a base material and a bioactive in contact with the base material, the bioactive having a proton binding site with a non-ionic form and an ionic form, the bioactive being less soluble in water when the proton binding site is in the non-ionic form than when the proton binding site is in the ionic form, wherein at least 5% w/w of the bioactive is present with the proton binding site in the non-ionic form and wherein the bioactive is not an anesthetic. Another embodiment provides such a medical device where the bioactive is an anesthetic and where the device is not a ureteral stent. Another aspect provides method of manufacturing such devices.
申请公布号
WO2008042228(A2)
申请公布日期
2008.04.10
申请号
WO2007US20875
申请日期
2007.09.27
申请人
MED INSTITUTE, INC.;RUANE, PATRICK, H.;ISCH, ANDREW, P.;PEREZ-SEGARRA, WALESKA