RECOMBINANT STRAIN Bacillus anthracis STIDeltaTPA-1 (pUB110PA-1) AS PRODUCER OF ANTHRAX MICROORGANISM ANTIGEN

摘要

FIELD: biotechnology, microbiology. ^ SUBSTANCE: invention proposes the recombinant strain B. anthrax STIDeltaTPA-1 (pUB110PA-1) that produces the anthrax microorganism protective antigen. The strain is obtained by transformation of the strain B. anthrax STIDeltaT with hybrid plasmid pUB110PA-1 DNA and deposited in GK of pathogenic microorganisms "Mikrob" at number KM-96. The strain is characterized by stability of hybrid replicon and high level of production of the protective antigen representing the main component of chemical anthrax vaccines, and safety in using. ^ EFFECT: valuable biological properties of strain. ^ 8 ex