IMIDAZOLIDINE DERIVATIVES, USES THEREFOR, PREPARATION THEREOF AND COMPOSITIONS COMPRISING SUCH

摘要

Compounds of formula (I): wherein X is O or S, R₁ is acyl, aldehyde, cycloalkyl, an optionally substituted alkyl, alkenyl or alkynyl, R₂ is H. alkyl, hydroxyalkyl, haloalkyl, alkenyl, or alkynyl; substituted alkyl; alkylcarbonyl; R₃and R₄ are H, halogen, alkyl, alkenyl, alkynyl, alkoxyl, alkylthio, hydroxyalkyl, haloalkyl, haloalkenyl, or haloalkynyl; or R₃ and R₄ form an, optionally aromatic or heterocyclic, optionally substituted ring, R₅ is H, halogen, trifluoromethyl, -CN, or -NO2; not all of R₃, R₄, and R₅ being H, R₆ and R₉ are H, halogen, OH; alkyl. hydroxyalkyl, alkoxyl, thioalkyl, haloalkyl, alkenyl, or alkynyl; R₇ and R₈ are H, halogen, OH, SH; alkoxyl or alkylthio optionally substituted by OH and/or halogen; one of R₇ and R₈ not being H or halogen; or one of R₇ and R₈ is a pharmaceutically acceptable ester or thioester grouping, or R₆ is C_1-3-alkyl or, together with either R₁ or R₂, represents C_1-3 alkylene or alkenylene linking group, optionally substituted by methyl, trifluoromethyl, OH, or halogen, and pharmaceutically acceptable salts and esters thereof, are useful as selective androgen modulators.