| 摘要 |
This invention relates to novel indazolyl derivatives of formula (Ia) and (Ib) useful as potassium channel modulating agents, and their use in the pr eparation of pharmaceutical compositions. Moreover the invention is directed to pharmaceutical compositions useful for the treatment or alleviation of d iseases or disorders associated with the activity of potassium- channels, in particular respiratory diseases, epilepsy, convulsions, seizures, absence s eizures, vascular spasms, coronary artery spasms, renal disorders, polycysti c kidney disease, bladder spasms, urinary incontinence, bladder outflow obst ruction, erectile dysfunction, gastrointestinal dysfunction, secretory diarr hoea, ischaemia, cerebral ischaemia, ischaemic heart, disease, angina pector is, coronary heart disease, autism, ataxia, traumatic brain injury, Parkinso n's disease, bipolar disorder, psychosis, schizophrenia, anxiety, depression , mania, mood disorders, dementia, memory and attention deficits, Alzheimer' s disease, amyotrophic lateral sclerosis (ALS), dysmenorrhea,narcolepsy, Rey naud's disease, intermittent claudication, Sjorgren's syndrome, arrhythmia, hypertension, myotonic muscle' dystrophia, spasticity, xerostomi, diabetes t ype II, hypehnsulinemia, premature labour, baldness, cancer, irritable bowel syndrome, immune suppression, migraine and pain.
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