摘要 |
<p>The present invention provides 13,13a-dihydroberberine derivatives as shown below, their physiologically acceptable salts, use and pharmaceutical composition comprising the said derivatives. The said 13,13a-dihydroberberine derivatives are glucose sorbefacient to muscle cells and have medical effects for improving glucose-tolerance and insulin-resistance, facilitating weight loss, relaxing fatty liver, etc, approved by tests to integer animals. The said compounds of the present invention can be used for treating diabetes mellitus, adiposity, fatty liver and their complications caused by insulin resistance.</p> |
申请人 |
SHANGHAI INSTITUE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES;LI, JIA;HU, LIHONG;YE, JIMING;LI, JINGYA;JAMES, DAVID, E;DRAEGEN, EDWARD, W;ZHANG, HANKUN;CHENG, ZHE |
发明人 |
HU, LIHONG;YE, JIMING;LI, JINGYA;JAMES, DAVID, E;DRAEGEN, EDWARD, W;ZHANG, HANKUN;CHENG, ZHE |