SPECIFIC HYDROLYSIS OF THE N-UNPROTECTED (R) -ESTER OF (3 ) -AMIN0-3-ARYLPR0PI0NIC ACID ESTERS

摘要

A process for the preparation of a 3-amino-3-arylpropionic acid ester that is enriched in the (S)-enantiomer to at least 80% ee, or the preparation of 3-amino-3-arylpropionic acid that is enriched in the (R)-enantiomer to at least 80% enantiomeric excess (ee), is disclosed. The process comprises enantioselectively hydrolyzing an enantiomeric mixture of 3- amino-3-arylpropionic acid esters, and recovering the optically active ester (S)-(I) which is not hydrolyzed. Use of an ester hydrolase obtained from Aspergillus in the process is also disclosed.