| 发明名称 |
CYANOALKYLAMINO-DERIVATE ALS PROTEASE-HEMMER |
| 摘要 |
The present invention is directed to novel cyanoalkylamino derivatives that are inhibitors of cysteine protease such as cathepsins K, S, B and L, in particular cathepsin K Pharmaceutical composition comprising these compounds, method of treating diseases mediated by unregulated cysteine protease activity, in particular cathepsin K utilizing these compounds and methods of preparing these compounds are also disclosed. |
| 申请公布号 |
DE60225316(D1) |
申请公布日期 |
2008.04.10 |
| 申请号 |
DE2002625316 |
申请日期 |
2002.11.13 |
| 申请人 |
AXYS PHARMACEUTICALS INC.;MERCK FROSST CANADA LTD. |
发明人 |
BLACK, CAMERON;CRANE, SHELDON N.;DAVIS, DANA;SETTI, EDUARDO L. |
| 分类号 |
A61K31/277;C07D295/08;A61K31/341;A61K31/381;A61K31/4164;A61K31/423;A61K31/426;A61K31/428;A61K31/4402;A61K31/4406;A61K31/4409;A61K31/4468;A61K31/455;A61K31/495;A61K31/496;A61K31/505;A61K31/5375;A61K31/663;A61K31/675;A61P1/18;A61P3/10;A61P5/14;A61P11/00;A61P11/06;A61P19/00;A61P19/02;A61P19/10;A61P21/04;A61P25/02;A61P25/28;A61P29/00;A61P35/00;A61P37/02;A61P37/08;A61P43/00;C07C317/44;C07C321/28;C07C323/60;C07C323/65;C07D211/58;C07D213/32;C07D213/40;C07D213/52;C07D213/70;C07D213/74;C07D213/75;C07D213/81;C07D213/82;C07D233/84;C07D239/38;C07D263/58;C07D277/16;C07D277/20;C07D277/42;C07D277/74;C07D295/12;C07D295/18;C07D295/20;C07D307/38;C07D333/20 |
主分类号 |
A61K31/277 |
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