摘要 |
The invention concerns a substance for restoring normal co-expression and interaction between LOX and NRAGE proteins. In particular, the invention concerns the use of an effective amount of at least one substance modulating the expression and/or the activity of LOX having the sequence ID N°1 and/or modulating the expression and/or the activity of NRAGE having the sequence ID N°2 for making a composition for modulating the interaction between the LOX and NRAGE proteins so as to regulate the balance between the phenomena of proliferating cells, of differentiation and apoptosis, in particular in cases where the interaction between LOX and NRAGE proteins is absent or altered. The invention enables in particular skin aging, lichen planus, a graft-versus-host reaction disease, an eczema, a psoriasis, and a cancer, in particular an epithelial cancer, particularly an epithelial skin cancer, of basocellular type, or of spinocellular type to prevented or treated. |
申请人 |
ENGELHARD LYON;CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE;UNIVERSITE CLAUDE BERNARD LYON 1;BOUEZ, CHARBEL;GLEYZAL, CLAUDINE;ORLY, ISABELLE;ANDRE, VALERIE;SOMMER, PASCAL;REYMERMIER, CORINNE;DAMOUR, ODILE;PERRIER, ERIC |
发明人 |
BOUEZ, CHARBEL;GLEYZAL, CLAUDINE;ORLY, ISABELLE;ANDRE, VALERIE;SOMMER, PASCAL;REYMERMIER, CORINNE;DAMOUR, ODILE;PERRIER, ERIC |