发明名称 |
Silk-Based Drug Delivery System |
摘要 |
The present invention provides for novel sustained release silk-based delivery systems. The invention further provides methods for producing such formulations. In general, a silk fibroin solution is combined with a therapeutic agent to form a silk fibroin article. The article is then treated in such a way as to alter its conformation. The change in conformation increases its crytallinity or liquid crystallinity, thus controlling the release of a therapeutic agent from the formulation. This can be accomplished as single material carriers or in a layer-by-layer fashion to load different therapeutic agents or different concentrations of these agents in each layer.
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申请公布号 |
US2008085272(A1) |
申请公布日期 |
2008.04.10 |
申请号 |
US20050628930 |
申请日期 |
2005.06.13 |
申请人 |
TRUSTEES OF TUFTS COLLEGE |
发明人 |
KAPLAN DAVID L.;LORENZ MEINEL |
分类号 |
A61K38/02;A61K9/70;A61K31/70;A61K38/17;A61K38/39;A61K39/395;A61K47/00;A61K47/46 |
主分类号 |
A61K38/02 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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