| 摘要 |
The present invention provides the amino acid and nucleic acid sequences of heavy and light chain complementarity determining regions of tumor specific binding proteins. In particular, the present invention provides an antibody which comprises at least one heavy chain variable region (VH) that comprises three CDRs, wherein said heavy chain variable region comprises: (i) a heavy chain CDR1 domain that comprises the amino acid sequence SYSMN (SEQ ID NO. 35), (ii) a heavy chain CDR2 domain that comprises the amino acid sequence SISSSSSYIYYADSVKG (SEQ ID NO. 39), and (iii) a heavy chain CDR3 domain that comprises the amino acid sequence SSGWYDGEFDP (SEQ ID NO: 40), wherein said antibody is capable of specifically binding to CD98hc or fragments of CD98hc. |
