ORAL RECOMBINANT HELICOBACTER PYLORI VACCINE AND PREPARING METHOD THEREOF

摘要

A recombinant protein used in the immunoprophylaxis against human's infection of Helicobacter pylori, a degradable slow-release oral microsphere vaccine comprising the recombinant protein, and the preparing methods thereof are provided. The recombinant protein contains two subunits: one is subunit LTA2B, which is the fusion of subunit A2 and subunit B of heat labile toxin (LTA2B) from enterotoxigenic Escherichia coli; the other is subunit urease B from Helicobacter pylori.